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Article Dans Une Revue Multifunctional Materials Année : 2019

UV-triggered photoinsertion of contrast agent onto polymer surfaces for in vivo MRI-visible medical devices

Lucie Allègre
Christophe Goze-Bac
Hubert Taillades
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Résumé

Polymeric materials are largely employed for the manufacturing of implants for various reasons, but they are typically invisible by conventional imaging methods. To improve surgical procedure and postoperative implant follow-up though, biomaterials are needed which allow an accurate and efficient imaging. Here, we present a direct and versatile strategy that allows to covalently immobilize T1 magnetic resonance imaging (MRI) contrast agents at the surface of various clinically relevant polymeric biomaterials. An aryl-azide bearing complex of 1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and gadolinium (Gd) has been synthesized for easy photografting onto polymer surfaces. Polycaprolactone (PCL), polylactide (PLA), polyurethane (PU), polyetheretherketone (PEEK) and polypropylene (PP) have been selected as clinically relevant substrates and successfully functionalized with the photosensitive MRI probe DOTA/Gd. Following in vitro assessment of their biocompatibility and MRI visibility, commercial MRI-visible PP hernia repair meshes (MRI-meshes) have been prepared. MRI-meshes have been implanted in rats for in vivo evaluation of their imaging capacities over 1 month. Histological evaluation and Gd biodistribution studies have been carried out confirming the potential of this straightforward approach to simply yield imageable medical devices.
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Dates et versions

hal-02376342 , version 1 (25-08-2021)

Identifiants

Citer

Anita Schulz, Laurent Lemaire, Audrey Bethry, Lucie Allègre, Maida Cardoso, et al.. UV-triggered photoinsertion of contrast agent onto polymer surfaces for in vivo MRI-visible medical devices. Multifunctional Materials, 2019, 2 (2), pp.024001. ⟨10.1088/2399-7532/ab0f81⟩. ⟨hal-02376342⟩
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