Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Clinical Infectious Diseases Année : 2019

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study

Romain Sonneville
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Résumé

In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day-28 mortality than others (80% vs 12%; p=0.011).
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Dates et versions

hal-02383473 , version 1 (27-11-2019)

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Sylvie Behillil, Faten May, Slim Fourati, Charles-Edouard Luyt, Thomas Chicheportiche, et al.. Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study. Clinical Infectious Diseases, 2019, ⟨10.1093/cid/ciz904⟩. ⟨hal-02383473⟩
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