Animal models of binge drinking, current challenges to improve face validity - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Neuroscience and Biobehavioral Reviews Année : 2019

Animal models of binge drinking, current challenges to improve face validity

Résumé

Binge drinking (BD), i.e., consuming a large amount of alcohol in a short period of time, is an increasing public health issue. Though no clear definition has been adopted worldwide the speed of drinking seems to be a keystone of this behavior. Developing relevant animal models of BD is a priority for gaining a better characterization of the neurobiological and psychobiological mechanisms underlying this dangerous and harmful behavior. Until recently, preclinical research on BD has been conducted mostly using forced administration of alcohol, but more recent studies used scheduled access to alcohol, to model more voluntary excessive intakes, and to achieve signs of intoxications that mimic the human behavior. The main challenges for future research are discussed regarding the need of good face validity, construct validity and predictive validity of animal models of BD.
Fichier principal
Vignette du fichier
S0149763418301234.pdf (1.4 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02397531 , version 1 (20-07-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Jérôme Jeanblanc, Benjamin Rolland, Fabien Gierski, Margaret Martinetti, Mickaël Naassila. Animal models of binge drinking, current challenges to improve face validity. Neuroscience and Biobehavioral Reviews, 2019, 106, pp.112-121. ⟨10.1016/j.neubiorev.2018.05.002⟩. ⟨hal-02397531⟩
44 Consultations
145 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More