Labelling IL-18 with alkaloids: towards the use of cytokines as carrier molecules in chemotherapy
Résumé
Recent in vivo models demonstrated that immune checkpoint cancer therapy can be improved by injecting interleukine (IL)-18, a proinflammatory cy-tokine of the IL-1 family. Aiming to enhance the beneficial action of citokines in cancer treatments, we used here docking, non-covalent interaction analysis and molecular dynamics simulation to determine their ability for embedding alkaloid-based drugs. According to our simulations, three alkaloids with an-ticancer activity, e.g., paclitaxel, vincristine and vinorelbine, are efficiently retained in the central cavity of IL-18. The reported results pave a new synthetic route for designing novel bifunctional carrier-cargo systems with enhanced anticancer activity.
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Banegas-Luna et al. - 2019 - Labeling IL-18 with alkaloids toward the use of c.pdf (3.99 Mo)
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