Mycobacterium tuberculosis releases an antacid that remodels phagosomes
Résumé
Mycobacterium tuberculosis (Mtb) is world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. Here we show that 1-TbAd is a naturally evolved phagolysosome disruptor. 1-TbAd is highly prevalent among patient-derived Mtb strains, where it is among the most
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nihms-1060820.pdf (2.25 Mo)
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NIHMS1060820-supplement-figures_with_legends (2).pdf (20.23 Mo)
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