Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Nanotechnology Année : 2019

Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model

Résumé

In this work, we describe the design and the use of a novel theranostic hybrid nanocomposite made of an iron oxide core and a mesoporous silica shell (IO@MS) of ca. 30 nm coated by human serum albumin (HSA) layer for magnetic resonance imaging and drug delivery applications. The porosity of IO@MS nanoparticles was loaded with an antitumoral drug, Doxorubicin (Dox) reaching a high drug loading capacity (DLC) of 34 w%. To entrap the drug, a tight HSA coating held via isobutyramide (IBAM) binders was deposited. We show that this protein nanoassembly entraps the drugs efficiently and behaves as an innovative enzyme-sensitive gatekeeper that is degraded upon protease action. Finally we assess the Dox release in a 3D cell model via confocal imaging and its cytotoxicity is shown by growth inhibition studies on liver cancer cell spheroids
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Dates et versions

hal-02413369 , version 1 (25-11-2020)

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Mathilde Ménard, Florent Meyer, Christine Affolter-Zbaraszczuk, Morgane Rabineau, Alexandre Adam, et al.. Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model. Nanotechnology, 2019, 30 (17), pp.174001. ⟨10.1088/1361-6528/aafe1c⟩. ⟨hal-02413369⟩
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