%0 Journal Article %T Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation %+ Biothérapies des maladies génétiques et cancers %+ U1211 Laboratoire Maladies Rares: Génétique et Métabolisme %+ Maladies Rares - Génétique et Métabolisme (MRGM) %+ Plateforme génomique fonctionnelle (PGFB) %+ Centre Génomique Fonctionnelle Bordeaux [Bordeaux] (CGFB) %+ Centre de Transfusion Sanguine Aquitaine-Limousin (CTS AQUITAINE-LIMOUSIN) %+ Laboratoire Lésions des Acides Nucléiques (LAN) %+ Service de génétique médicale %+ Centre de résonance magnétique des systèmes biologiques (CRMSB) %+ Physiopathologie mitochondriale %+ Transfert de gènes à visée thérapeutique dans les cellules souches %A Hosseini, Mohsen %A Dousset, Léa %A Mahfouf, Walid %A Serrano-Sanchez, Martin %A Redonnet-Vernhet, Isabelle %A Mesli, Samir %A Kasraian, Zeinab %A Obre, Emilie %A Bonneu, Marc %A Claverol, Stephane %A Vlaski, Marija %A Ivanovic, Zoran %A Rachidi, Walid %A Douki, Thierry %A Taieb, Alain %A Bouzier-Sore, Anne-Karine %A Rossignol, Rodrigue %A Rezvani, Hamid Reza %< avec comité de lecture %@ 2211-1247 %J Cell Reports %I Elsevier Inc %V 23 %N 12 %P 3621-3634 %8 2018 %D 2018 %R 10.1016/j.celrep.2018.05.060 %K cancer initiation, metabolic remodeling, dihydroorotate dehydrogenase, DHODH, ultraviolet B radiation, UVB, DNA repair, TFAM, glutaminolysis, skin cancer, squamous cell carcinoma, SCC %Z Life Sciences [q-bio]/Cancer %Z Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] %Z Life Sciences [q-bio]/Human health and pathology/DermatologyJournal articles %X Graphical Abstract Highlights d Specific metabolic modifications precede UVB-induced primary tumor formation d DHODH fuels mitochondrial respiration to coordinate DNA repair and ATP synthesis d Respiration-linked nucleotide synthesis is necessary for primary skin tumor formation d Impairment of ETC blocks neoplastic transformation of keratinocytes In Brief Hosseini et al. show that specific metabolic modifications occur at a very early stage of photocarcinogenesis. Those modifications ensure the coordination of ATP generation, persistent nucleotide biosynthesis and repair of DNA damage, which all play an important role in defining of epidermal cell fate. %G English %2 https://cnrs.hal.science/hal-02421137/document %2 https://cnrs.hal.science/hal-02421137/file/PIIS2211124718308246.pdf %L hal-02421137 %U https://cnrs.hal.science/hal-02421137 %~ INSERM %~ CEA %~ UGA %~ CNRS %~ INAC-SCIB %~ DSM-INAC %~ CEA-DRF %~ IRIG %~ CEA-GRE %~ CRMSB %~ TEST-HALCNRS %~ UGA-COMUE