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Article Dans Une Revue Cell Research Année : 2019

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

Takahiro Yamazaki
  • Fonction : Auteur
Maria Roberti
Miles Andrews
Gladys Ferrere
Gautier Stoll
Stefano Ugel
Shin Foong Ngiow
  • Fonction : Auteur
Armelle Prévost-Blondel
  • Fonction : Auteur
  • PersonId : 919945
Pierre-Olivier Gaudreau
  • Fonction : Auteur
Vancheswaran Gopalakrishnan
  • Fonction : Auteur
Christophe Klein
Mark Smyth
  • Fonction : Auteur
Guido Kroemer
Vincenzo Bronte
  • Fonction : Auteur

Résumé

PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy. Delineating mechanisms of secondary resistance to this strategy is increasingly important. Here, we identified the deleterious role of signaling via the type I interferon (IFN) receptor in tumor and antigen presenting cells, that induced the expression of nitric oxide synthase 2 (NOS2), associated with intratumor accumulation of regulatory T cells (Treg) and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody (mAb). Sustained IFNβ transcription was observed in resistant tumors, in turn inducing PD-L1 and NOS2 expression in both tumor and dendritic cells (DC). Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb, pharmacological or genetic inhibition of NOS2 maintained long-term control of tumors by PD-1 blockade, through reduction of Treg and DC activation. Resistance to immunotherapies, including anti-PD-1 mAb in melanoma patients, was also correlated with the induction of a type I IFN signature. Hence, the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy.
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Dates et versions

hal-02461559 , version 1 (07-03-2024)

Identifiants

Citer

Nicolas Jacquelot, Takahiro Yamazaki, Maria Roberti, Connie Duong, Miles Andrews, et al.. Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade. Cell Research, 2019, 29 (10), pp.846-861. ⟨10.1038/s41422-019-0224-x⟩. ⟨hal-02461559⟩
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