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Article Dans Une Revue Cell and Tissue Research Année : 2006

Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation

Sylvie Claeysen
Carine Becamel
Aline Dumuis
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Philippe Marin

Résumé

Serotonin (5-hydroxytryptamine, 5-HT) is, without doubt, the neurotransmitter for which the number of receptors is the highest. Fifteen genes encoding functional 5-HT receptors have been cloned in mammalian brain. 5-HT3 receptors are ionotropic receptors, whereas all the others are metabotropic G-protein-coupled receptors (GPCRs). 5-HT receptor diversity is further increased by post-genomic modifications, such as alternative splicing (up to 10 splice variants for the 5-HT4 receptor) or by mRNA editing in the case of 5-HT2C receptors. The cellular and behavioral implications of 5-HT2C receptor editing are of great physiological importance. Signaling of 5-HT receptors involves a great variety of pathways, but only some of these have been demonstrated in neurons. The classical view of neurotransmitter receptors localized within the synaptic cleft cannot be applied to 5-HT receptors, which are mostly (but not exclusively) localized at extra-synaptic locations either pre-or post-synaptically. 5-HT receptors are engaged in pre-or post-synaptic complexes composed of many GPCR-interacting proteins. The functions of these proteins are starting to be revealed. These proteins have been implicated in targeting, trafficking to or from the membrane, desensitization, and fine-tuning of signaling.

Domaines

Neurobiologie
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Dates et versions

hal-02484323 , version 1 (19-02-2020)

Identifiants

Citer

Joël Bockaert, Sylvie Claeysen, Carine Becamel, Aline Dumuis, Philippe Marin. Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. Cell and Tissue Research, 2006, 326 (2), pp.553-572. ⟨10.1007/s00441-006-0286-1⟩. ⟨hal-02484323⟩
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