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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2019

Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3

Résumé

The scorpion toxin AmmTx3 is a specific blocker of Kv4 channels. It was shown to have interesting potential for neurological disorders. In this study, we report the first chemical synthesis of AmmTx3 by using the native chemical ligation strategy and validate its biological activity. We determined its 3D structure by nuclear magnetic resonance spectroscopy, and pointed out that AmmTx3 possesses the well-known CSαβ structural motif, which is found in a large number of scorpion toxins. Overall, this study establishes an easy synthetic access to biologically active AmmTx3 toxin.

Domaines

Chimie
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Dates et versions

hal-02522016 , version 1 (27-03-2020)

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Claude Zoukimian, Hervé Meudal, Stephan de Waard, Karima Ait Ouares, Sébastien Nicolas, et al.. Synthesis by native chemical ligation and characterization of the scorpion toxin AmmTx3. Bioorganic and Medicinal Chemistry, 2019, 27 (1), pp.247-253. ⟨10.1016/j.bmc.2018.12.009⟩. ⟨hal-02522016⟩
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