The Gene Coding for Interferon-γ Is Linked to the D12S335 and D12S313 Microsatellites and to the MDM2 Gene - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Genomics Année : 1995

The Gene Coding for Interferon-γ Is Linked to the D12S335 and D12S313 Microsatellites and to the MDM2 Gene

J.F. Bureau
  • Fonction : Auteur
F. Bihl
  • Fonction : Auteur
M. Brahic
  • Fonction : Auteur

Résumé

Interferon-gamma is a cytokine with multiple effects. It interferes with the replication of several viruses and plays a key role in the regulation of immune responses. Therefore, the gene coding for interferon-gamma could be implicated in the susceptibility of humans to several diseases. We have localized this gene close to the D12S335 and D12S313 microsatellites on both the physical and the genetic maps of the human genome. We also physically mapped this gene close to the MDM2 locus on chromosome band 12q15. Finally, we describe the organization of the Ifg, Myf-6, Mdm1, and Mdm2 loci on mouse chromosome 10, in a region syntenic to human chromosome band 12q15.

Dates et versions

hal-02526306 , version 1 (31-03-2020)

Identifiants

Citer

J.F. Bureau, F. Bihl, M. Brahic, D. Le Paslier. The Gene Coding for Interferon-γ Is Linked to the D12S335 and D12S313 Microsatellites and to the MDM2 Gene. Genomics, 1995, 28 (1), pp.109-112. ⟨10.1006/geno.1995.1114⟩. ⟨hal-02526306⟩
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