Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders - CNRS - Centre national de la recherche scientifique Access content directly
Journal Articles Clinical Cancer Research Year : 2010

Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders

Abstract

Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling pathway is constitutively activated in melanoma. AZD6244 blocks MEK1/2, inhibiting ERK phosphorylation. We focus on associated cutaneous toxicity and we attempt to understand the underlying pathophysiology and design treatment strategies.

Dates and versions

hal-02526751 , version 1 (31-03-2020)

Identifiers

Cite

Karin Schad, Katrin Baumann Conzett, Marie Zipser, Valérie Enderlin, Jivko Kamarashev, et al.. Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibition Results in Biphasic Alteration of Epidermal Homeostasis with Keratinocytic Apoptosis and Pigmentation Disorders. Clinical Cancer Research, 2010, 16 (3), pp.1058-1064. ⟨10.1158/1078-0432.CCR-09-1766⟩. ⟨hal-02526751⟩

Collections

CNRS INRA INRAE
41 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More