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Article Dans Une Revue Journal of Neuroscience Methods Année : 1997

Induction and duration of long-term potentiation in the hippocampus of the freely moving mouse

Résumé

We describe a simple method, using readily available minaturised components, for inducing and monitoring long-term potentiation (LTP) at perforant path-granule cell synapses in the dentate gyrus of the freely moving mouse. Tetanic stimulation induced LTP of the field EPSP and the population spike which persisted for more than 24 h but was not present 10 days after the tetanus. The potentiation of the population spike was proportionately greater than the potentiation of the EPSP (E-S potentiation). Induction of LTP was blocked by intraperitoneal injections of the N-methyl-D-aspartate (NMDA) receptor antagonist, 3-((RS)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP).

Dates et versions

hal-02538067 , version 1 (09-04-2020)

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Citer

Sabrina Davis, Timothy V. P. Bliss, Gérard Dutrieux, Serge Laroche, Michael L. Errington. Induction and duration of long-term potentiation in the hippocampus of the freely moving mouse. Journal of Neuroscience Methods, 1997, 75 (1), pp.75-80. ⟨10.1016/s0165-0270(97)00053-8⟩. ⟨hal-02538067⟩
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