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Article Dans Une Revue Médecine/Sciences Année : 2020

Lung organoids

Les organoïdes pulmonaires

Résumé

As burden of chronic respiratory diseases is constantly increasing, improving in vitro lung models is essential in order to reproduce as closely as possible the complex pulmonary architecture, responsible for oxygen uptake and carbon dioxide clearance. The study of diseases that affect the respiratory system has benefited from in vitro reconstructions of the respiratory epithelium with inserts in air/liquid interface (2D) or in organoids able to mimic up to the arborescence of the respiratory tree (3D). Recent development in the fields of pluripotent stem cells-derived organoids and genome editing technologies has provided new insights to better understand pulmonary diseases and to find new therapeutic perspectives.
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Dates et versions

hal-02560622 , version 1 (29-06-2020)

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Chloé Bourguignon, Charlotte Vernisse, Joffrey Mianné, Mathieu Fieldes, Engi Ahmed, et al.. Les organoïdes pulmonaires. Médecine/Sciences, 2020, 36 (4), pp.382-388. ⟨10.1051/medsci/2020056⟩. ⟨hal-02560622⟩
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