Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012–2013 - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Malaria Journal Année : 2014

Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012–2013

Didier Ménard

Résumé

The emergence of Plasmodium falciparum resistance to artemisinin and its derivatives, manifested as delayed parasite clearance following the treatment, has developed in Southeast Asia. The spread of resistance to artemisinin from Asia to Africa may be catastrophic for malaria control and elimination worldwide. Recently, mutations in the propeller domain of the Kelch 13 (k13) gene (PF3D71343700) were associated with in vitro resistance to artemisinin and with delayed clearance after artemisinin treatment in southern Asia. The aim of the study was to characterize the genetic variability of k13 and to evaluate the molecular resistance to artemisinin for the first time in Senegal.
Fichier principal
Vignette du fichier
1475-2875-13-472.pdf (269.63 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02560659 , version 1 (01-02-2022)

Licence

Paternité

Identifiants

Citer

Marylin Torrentino-Madamet, Bécaye Fall, Nicolas Benoit, Cheikhou Camara, Remy Amalvict, et al.. Limited polymorphisms in k13 gene in Plasmodium falciparum isolates from Dakar, Senegal in 2012–2013. Malaria Journal, 2014, 13 (1), pp.472. ⟨10.1186/1475-2875-13-472⟩. ⟨hal-02560659⟩
81 Consultations
41 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More