Genomes shed light on the secret life of <em>Candida glabrata</em>: not so asexual, not so commensal - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Current Genetics Année : 2019

Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal

Résumé

Candida glabrata is an opportunistic yeast pathogen, whose incidence has increased over the last decades. Despite its genus name, this species is actually more closely related to the budding yeast Saccharomyces cerevisiae than to other Candida pathogens, such as Candida albicans. Hence, C. glabrata and C. albicans must have acquired the ability to infect humans independently, which is reflected in the use of different mechanism for virulence, and survival in the host. Yet, research on C. glabrata suffers from assumptions carried over from the more studied C. albicans. Regarding the adaptation of C. glabrata to the human host, the prejudice was that, just as C. albicans, C. glabrata is a natural human commensal that turns deadly when immune defenses weaken. It was also considered asexual, as no one has observed mating, diploids, or spores, despite great efforts. However, the recent analysis of whole genomes from globally distributed C. glabrata isolates have shaken these assumptions. C. glabrata seems to be only secondarily associated to humans, as indicated by a lack of co-evolution with its host, and genomic footprints of recombination shows compelling evidence that this yeast is able to have sex. Here, we discuss the implications of this and other recent findings and highlight the new questions opened by this change in paradigm.
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hal-02619728 , version 1 (02-02-2024)

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Toni Gabaldón, Cécile Fairhead. Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal. Current Genetics, 2019, 65 (1), pp.93-98. ⟨10.1007/s00294-018-0867-z⟩. ⟨hal-02619728⟩
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