Synthesis of novel series of 7,7 '-(substituted methylene) bis-imidazo 1,2-b pyrazoles via an acid catalyzed one-pot three-component reaction - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue New Journal of Chemistry Année : 2018

Synthesis of novel series of 7,7 '-(substituted methylene) bis-imidazo 1,2-b pyrazoles via an acid catalyzed one-pot three-component reaction

Résumé

An efficient and rapid synthesis of new series of N-alkyl-2-aryl-5H-imidazo[1,2-b]pyrazoles has been achieved in high yields through a three-component reaction of 3-amino-4-substituted pyrazoles, aromatic aldehydes and isocyanides mediated by acid catalysts. In addition, a novel and straightforward approach to a sequential one-pot multicomponent reaction has been developed for the synthesis of hitherto undescribed 7,7'-(substituted methylene) bis-imidazo[1,2-b] pyrazoles, starting from 3-amino-5-substituted (or unsubstituted) pyrazoles, various aldehydes and isocyanides. The reaction was performed under mild conditions in the presence of inexpensive zirconium(IV) chloride as a catalyst. A library of 22 products was obtained in moderate to good yields.
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hal-02620165 , version 1 (25-05-2020)

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Mohsine Driowya, Hassan Allouchi, Jose Manuel Gally, Pascal Bonnet, Gérald Guillaumet. Synthesis of novel series of 7,7 '-(substituted methylene) bis-imidazo 1,2-b pyrazoles via an acid catalyzed one-pot three-component reaction. New Journal of Chemistry, 2018, 42 (8), pp.5728-5741. ⟨10.1039/c7nj05088g⟩. ⟨hal-02620165⟩
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