G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway? - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Frontiers in Endocrinology Année : 2018

G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?

Résumé

G protein-coupled receptors (GPCRs) exert their physiological function by transducing a complex signaling network that coordinates gene expression and dictates the phenotype of highly differentiated cells. Much is known about the gene networks they transcriptionally regulate upon ligand exposure in a process that takes hours before a new protein is synthesized. However, far less is known about GPCR impact on the translational machinery and subsequent mRNA translation, although this gene regulation level alters the cell phenotype in a strikingly different timescale. In fact, mRNA translation is an early response kinetically connected to signaling events, hence it leads to the synthesis of a new protein within minutes following receptor activation. By these means, mRNA translation is responsive to subtle variations of the extracellular environment. In addition, when restricted to cell subcellular compartments, local mRNA translation contributes to cell micro-specialization, as observed in synaptic plasticity or in cell migration. The mechanisms that control where in the cell an mRNA is translated are starting to be deciphered. But how an extracellular signal triggers such local translation still deserves extensive investigations. With the advent of high-throughput data acquisition, it now becomes possible to review the current knowledge on the translatome that some GPCRs regulate, and how this information can be used to explore GPCR-controlled local translation of mRNAs.
Fichier principal
Vignette du fichier
2018_Trefier_Frontiers in Endocrinology_1.pdf (615.25 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02621667 , version 1 (26-05-2020)

Licence

Paternité

Identifiants

Citer

Aurélie Trefier, Lucie P. Pellissier, Astrid Musnier, Eric Reiter, Florian Guillou, et al.. G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?. Frontiers in Endocrinology, 2018, 9, ⟨10.3389/fendo.2018.00017⟩. ⟨hal-02621667⟩
26 Consultations
66 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More