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Article Dans Une Revue Immunity Année : 2018

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

Andreia C. Lino
  • Fonction : Auteur correspondant
Quentin Simon
Imme Sakwa
  • Fonction : Auteur
Sarantis Korniotis
  • Fonction : Auteur
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  • IdRef : 179486225

Résumé

B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also express the inhibitory receptors CD200, PD-L1, and PD-L2. They develop from various B cell subsets in a B cell receptor (BCR)-dependent manner independently of microbiota in naive mice. After challenge they upregulate IL-10 expression via a Toll-like receptor-driven mechanism within hours and without proliferating. This function is associated with a unique transcriptome and epigenome, including the lowest amount of DNA methylation at the Il10 locus compared to other B cell subsets. Their augmented accumulation in naive mutant mice with increased BCR signaling correlates with the inhibition of memory T cell formation and vaccine efficacy after challenge. These natural regulatory plasma cells may be of broad relevance for disease intervention.
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Dates et versions

hal-02622086 , version 1 (26-05-2020)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Andreia C. Lino, - van Duc Dang, Vicky Lampropoulou, Anna Welle, Jara Joedicke, et al.. LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells. Immunity, 2018, 49 (1), pp.120 - +. ⟨10.1016/j.immuni.2018.06.007⟩. ⟨hal-02622086⟩
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