Comparative genomics of the major parasitic worms - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Nature Genetics Année : 2019

Comparative genomics of the major parasitic worms

Avril Coghlan (1) , Rahul Tyagi (2) , James A. Cotton (1) , Nancy Holroyd (1) , Bruce A. Rosa (2) , Isheng Jason Tsai (3, 4, 5) , Dominik R. Laetsch (6) , Robin N. Beech (7) , Tim A. Day (8, 9) , Kymberlie Hallsworth-Pepin (2) , Huei-Mien Ke (3) , Tzu-Hao Kuo (3) , Tracy J. Lee (3) , John Martin (2) , Rick M. Maizels (10) , Prudence Mutowo (11) , Philip Ozersky (2) , John Parkinson (12) , Adam J. Reid (1) , Neil D. Rawlings (11) , Diogo M. Ribeiro (1, 13) , Lakshmipuram Seshadri Swapna (12) , Eleanor Stanley (1) , David W. Taylor (6) , Nicolas J. Wheeler (14, 8) , Mostafa Zamanian (14) , Xu Zhang (2) , Fiona Allan (15) , Judith E. Allen (16) , Kazuhito Asano (17) , Simon A. Babayan (6, 10) , Germanus Bah (18) , Helen Beasley (1) , Hayley M. Bennett (1) , Stewart A. Bisset (19) , Estela Castillo (20) , Joseph Cook (21) , Philip J. Cooper (22, 23) , Teresa Cruz-Bustos (24) , Carmen Cuellar (25) , Eileen Devaney (10) , Stephen R. Doyle (1) , Mark L. Eberhard (26, 27) , Aidan Emery (15) , Keeseon S. Eom (28) , John S. Gilleard (29) , Daria Gordon (1) , Yvonne Harcus (6, 30) , Bhavana Harsha (1) , John M. Hawdon (31) , Dolores E. Hill (32) , Jane Hodgkinson (33) , Petr Horák (34) , Kevin L. Howe (11) , Thomas Huckvale (1) , Martin Kalbe (35) , Gaganjot Kaur (6, 12) , Taisei Kikuchi (36) , Georgios Koutsovoulos (37, 6) , Sujai Kumar (38, 39) , Andrew R. Leach (11) , Jane Lomax (1) , Benjamin Makepeace (40) , Jacqueline B. Matthews (41) , Antonio Muro (42) , Noel Michael O'Boyle (43) , Peter D. Olson (15) , Antonio Osuna (24) , Felix Partono (44) , Kenneth Pfarr (45) , Gabriel Rinaldi (1) , Pilar Foronda (46) , David Rollinson (15) , Mercedes Gomez Samblas (24) , Hiroshi Sato (47) , Manuela Schnyder (48) , Tomas Scholz (49) , Myriam Shafie (1) , Vincent N. Tanya (18) , Rafael Toledo (50) , Alan Tracey (1) , Joseph F. Urban (32) , Lian-Chen Wang (51) , Dante Zarlenga (32) , Mark L. Blaxter (6) , Makedonka Mitreva (2) , Matthew Berriman (1)
1 Wellcome Sanger Institute
2 Sch Med, McDonnell Genome Inst
3 Biodiversity Research Center
4 Department of Life Science
5 NTNU - National Taiwan Normal University
6 Edin. - University of Edinburgh
7 McGill University = Université McGill [Montréal, Canada]
8 ISU - Iowa State University
9 Institute for Global Food Security [Belfast]
10 University of Glasgow
11 European Molecular Biology Laboratory European Bioinformatics Institute
12 University of Toronto
13 AMU - Aix Marseille Université
14 University of Wisconsin-Madison
15 National History Museum
16 University of Manchester [Manchester]
17 Showa University
18 IRAD - Institut de Recherche Agricole pour le Développement [Yaoundé]
19 Agresearch Ltd
20 University of the Republic
21 The University of New Mexico [Albuquerque]
22 St. George’s Hospital University
23 UCE - Universidad Central del Ecuador
24 UGR - Universidad de Granada = University of Granada
25 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
26 Ctr Dis Control & Prevent
27 The Carter Center
28 Chungbuk National University
29 Univ Calgary, Dept Comparat Biol & Expt Med, Calgary, AB, Canada
30 Centre for Cardiovascular Science
31 GW - The George Washington University
32 USDA - United States Department of Agriculture
33 University of Liverpool
34 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
35 EBD - Estación Biológica de Doñana
36 University of Miyazaki
37 ISA - Institut Sophia Agrobiotech
38 Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland
39 Univ Edinburgh, Inst Evolutionary Biol, BaNG, Edinburgh, Midlothian, Scotland
40 Department of Infection Biology
41 MRI - Moredun Research Institute [Penicuik, UK]
42 Universidad de Salamanca
43 NextMove Software Ltd
44 UI - University of Indonesia
45 Institute for Medical Microbiology, Immunology, and Parasitology
46 ULL - Universidad de La Laguna [Tenerife - SP]
47 Yamaguchi University
48 UZH - Universität Zürich [Zürich] = University of Zurich
49 BIOLOGY CENTRE CAS - Biology Centre of the Czech Academy of Sciences
50 UV - Universitat de València
51 Chang Gung University [Taïwan]
Avril Coghlan
  • Fonction : Auteur correspondant
  • PersonId : 1070680

Connectez-vous pour contacter l'auteur
Kazuhito Asano
  • Fonction : Auteur
Stewart A. Bisset
  • Fonction : Auteur
Alan Tracey

Résumé

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

Dates et versions

hal-02626601 , version 1 (26-05-2020)

Identifiants

Citer

Avril Coghlan, Rahul Tyagi, James A. Cotton, Nancy Holroyd, Bruce A. Rosa, et al.. Comparative genomics of the major parasitic worms. Nature Genetics, 2019, 51 (1), pp.163-172. ⟨10.1038/s41588-018-0262-1⟩. ⟨hal-02626601⟩
81 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More