Use of an automated ACTH assay for the diagnosis of pituitary and adrenal-related diseases
Résumé
Objective
To evaluate Liaison Diasorin's automated ACTH assay.
Design
We investigated the limit of quantification (LOQ) and simulated the usage of the analyzer using our ACTH results database.
Results
The LOQ was close to the cut-off determining Cushing's syndrome ACTH dependency. 25% concentrations of normal subjects were lower than the LOQ. Although biased, the results were concordant with those of an IRMA assay.
Conclusion
This assay is not sensitive enough to diagnose ACTH-independent Cushing's syndrome.