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Article Dans Une Revue Clinical Biochemistry Année : 2011

Use of an automated ACTH assay for the diagnosis of pituitary and adrenal-related diseases

M. Bouton
  • Fonction : Auteur
B. Gatta
  • Fonction : Auteur
A. Tabarin
  • Fonction : Auteur

Résumé

Objective To evaluate Liaison Diasorin's automated ACTH assay. Design We investigated the limit of quantification (LOQ) and simulated the usage of the analyzer using our ACTH results database. Results The LOQ was close to the cut-off determining Cushing's syndrome ACTH dependency. 25% concentrations of normal subjects were lower than the LOQ. Although biased, the results were concordant with those of an IRMA assay. Conclusion This assay is not sensitive enough to diagnose ACTH-independent Cushing's syndrome.

Dates et versions

hal-02646423 , version 1 (29-05-2020)

Identifiants

Citer

Julie Brossaud, M. Bouton, B. Gatta, A. Tabarin, Jean-Benoît J.-B. Corcuff. Use of an automated ACTH assay for the diagnosis of pituitary and adrenal-related diseases. Clinical Biochemistry, 2011, 44 (13), pp.1160-1162. ⟨10.1016/j.clinbiochem.2011.06.002⟩. ⟨hal-02646423⟩
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