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Article Dans Une Revue Cellular and Molecular Life Sciences Année : 2003

Cholesterol homeostasis and function in neurons of the central nervous system.

Résumé

Cholesterol is a multifaceted molecule. First, it serves as an essential membrane component, as a cofactor for signaling molecules and as a precursor for steroid hormones; second, its synthesis, intercellular transport and intracellular distribution present a logistic tour de force requiring hundreds of cellular components, and third, it plays a crucial role in major human diseases. Despite intense research on this molecule, its metabolism in the central nervous system and its role in neuronal development and function are not well understood. Here I summarize recent results and hypotheses about how neurons maintain their cholesterol level and how cholesterol influences the establishment and maintenance of synaptic connections.

Dates et versions

hal-02875977 , version 1 (19-06-2020)

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Citer

Frank Pfrieger. Cholesterol homeostasis and function in neurons of the central nervous system.. Cellular and Molecular Life Sciences, 2003, 60 (6), ⟨10.1007/s00018-003-3018-7⟩. ⟨hal-02875977⟩

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