Inhibition of Cu‐Amyloid‐β by using Bifunctional Peptides with β‐Sheet Breaker and Chelator Moieties - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2012

Inhibition of Cu‐Amyloid‐β by using Bifunctional Peptides with β‐Sheet Breaker and Chelator Moieties

Résumé

Inhibition of toxic amyloid‐β (Aβ) aggregates and disruption of Cu‐Aβ with subsequent redox‐silencing of Cu have been considered promising strategies against Alzheimer's disease. The design and proof of concept of simple peptides containing a Cu‐chelating/redox‐silencing unit and an Aβ‐aggregation inhibition unit (β‐sheet breaker) is described (see scheme).

Dates et versions

hal-02909962 , version 1 (31-07-2020)

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Madeleine Jensen, Anne Canning, Sabri Chiha, Pierre Bouquerel, Jeppe Trudslev Pedersen, et al.. Inhibition of Cu‐Amyloid‐β by using Bifunctional Peptides with β‐Sheet Breaker and Chelator Moieties. Chemistry - A European Journal, 2012, 18 (16), pp.4836-4839. ⟨10.1002/chem.201103546⟩. ⟨hal-02909962⟩
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