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Pré-Publication, Document De Travail Année : 2020

Phox2a defines a developmental origin of the anterolateral system in mice and humans

R. Brian Roome
  • Fonction : Auteur
Farin B Bourojeni
  • Fonction : Auteur
Bishakha Mona
  • Fonction : Auteur
Shima Rastegar-Pouyani
  • Fonction : Auteur
Raphael Blain
  • Fonction : Auteur
Annie Dumouchel
  • Fonction : Auteur
Charleen Salesse
  • Fonction : Auteur
Megan Brookbank
  • Fonction : Auteur
Yorick Gitton
Jane E. Johnson
  • Fonction : Auteur
Alain Chédotal
Artur Kania
  • Fonction : Auteur

Résumé

Anterolateral system neurons relay pain, itch and temperature information from the spinal cord to pain-related brain regions, but the differentiation of these neurons and their specific contribution to pain perception remain poorly defined. Here, we show that virtually all mouse spinal neurons that embryonically express the autonomic system-associated Paired-like homeobox 2A (Phox2a) transcription factor innervate nociceptive brain targets, including the parabrachial nucleus and the thalamus. We define Phox2a anterolateral system neuron birth order, migration and differentiation, and uncover an essential role for Phox2a in the development of relay of nociceptive signals from the spinal cord to the brain. Finally, we also demonstrate that the molecular identity of Phox2a neurons is conserved in the human foetal spinal cord. The developmental expression of Phox2a as a uniting feature of anterolateral system neurons suggests a link between nociception and autonomic nervous system function.

Dates et versions

hal-02912288 , version 1 (05-08-2020)

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Citer

R. Brian Roome, Farin B Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, et al.. Phox2a defines a developmental origin of the anterolateral system in mice and humans. 2020. ⟨hal-02912288⟩
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