Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Organic Letters Année : 2020

Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles

Résumé

We report here a simple and robust gold-catalyzed annulation reaction, giving N- and O-spirocycles in good to excellent yields. We have prepared a library of protected amines and tertiary alcohols that give, upon cyclization with alkynes, a representative set of heterospirocycles and illustrate reaction compatibility with diverse functional groups. A change in catalytic activity is possible by modifying the solvent, and two original tricyclic spirocycles were synthesized in a tandem reaction.
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Dates et versions

hal-02916186 , version 1 (26-08-2020)

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Kossi Efouako Soklou, Hamid Marzag, Jean-Philippe Bouillon, Mathieu Marchivie, Sylvain Routier, et al.. Gold(I)-Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Alkynes: Access to Original Heterospirocycles. Organic Letters, 2020, 22 (15), pp.5973-5977. ⟨10.1021/acs.orglett.0c02070⟩. ⟨hal-02916186⟩
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