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Article Dans Une Revue Micromachines Année : 2020

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Alan Saul Alvarez-Suárez
  • Fonction : Auteur
Syed G. Dastager
  • Fonction : Auteur
Nina Bogdanchikova
  • Fonction : Auteur
Alexey Pestryakov
  • Fonction : Auteur
Juan Carlos Garcia-Ramos
  • Fonction : Auteur
Karla Juárez-Moreno
  • Fonction : Auteur
Yanis Toledano-Magaña
  • Fonction : Auteur
Elena Smolentseva
  • Fonction : Auteur
Juan Antonio Paz-Gonzalez
  • Fonction : Auteur
Tatiana Popova
  • Fonction : Auteur
Lyubov Rachkovskaya
  • Fonction : Auteur
Vadim Nimaev
  • Fonction : Auteur
Anastasia Kotlyarova
  • Fonction : Auteur
Maksim Korolev
  • Fonction : Auteur
Andrey Letyagin
  • Fonction : Auteur
Luis-Jesús Villarreal-Gómez
  • Fonction : Auteur

Résumé

Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al 2 O 3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58-60 • C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical Micromachines 2020, 11, 441 2 of 24 properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al 2 O 3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al 2 O 3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.
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Dates et versions

hal-02922920 , version 1 (26-08-2020)

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Alan Saul Alvarez-Suárez, Syed G. Dastager, Nina Bogdanchikova, Daniel Grande, Alexey Pestryakov, et al.. Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings. Micromachines, 2020, 11 (4), pp.441. ⟨10.3390/mi11040441⟩. ⟨hal-02922920⟩
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