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Article Dans Une Revue Seminars in cell & developmental biology Année : 2011

Functional roles of synapsin: lessons from invertebrates.

Simona Candiani
  • Fonction : Auteur
Mirella Ghirardi
  • Fonction : Auteur
Piergiorgo Montarolo
  • Fonction : Auteur

Résumé

Data collected from the invertebrate models have allowed to establish several of the basic mechanisms of neuronal function and pioneered the studies on the molecular and cellular mechanisms involved in behavioral responses. In the 1970s, the first synaptic proteins--including synapsin--being identified, the first attempts to evaluate their synaptic function were done using available invertebrate preparations. Forty years later, it appears that deductions made from invertebrate synapsin were largely validated in vertebrates, probably reflecting the phylogenic conservation of some specific synapsin sub-domains. In this review, in light of insights got from invertebrate preparations, we discuss the role of synapsin in synaptogenesis and synaptic function, especially on short term plasticity.
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Dates et versions

hal-02933961 , version 1 (08-09-2020)

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Yann Humeau, Simona Candiani, Mirella Ghirardi, Bernard Poulain, Piergiorgo Montarolo. Functional roles of synapsin: lessons from invertebrates.. Seminars in cell & developmental biology, 2011, 22 (4), pp.425-433. ⟨10.1016/j.semcdb.2011.07.018⟩. ⟨hal-02933961⟩

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