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Article Dans Une Revue Anti-Cancer Agents in Medicinal Chemistry Année : 2020

Anti-Cancer Activity of Curcumin on Multiple Myeloma

Hamed Mirzaei
  • Fonction : Auteur
Hossein Bagheri
  • Fonction : Auteur
Faezeh Ghasemi
  • Fonction : Auteur
Jaber Khoi
  • Fonction : Auteur
Mohammad Pourhanifeh
  • Fonction : Auteur
Yvan Heyden
  • Fonction : Auteur
Erfan Mortezapour
  • Fonction : Auteur
Ali Nikdast
  • Fonction : Auteur
Haroon Khan
  • Fonction : Auteur
Amirhossein Sahebkar
  • Fonction : Auteur

Résumé

Multiple Myeloma (MM) is the third most common and deadly hematological malignancy, which is characterized by a progressive monoclonal proliferation within the bone marrow. MM is cytogenetically heterogeneous with numerous genetic and epigenetic alterations, which lead to a wide spectrum of signaling pathways and cell cycle checkpoint aberrations. MM symptoms can be attributed to CRAB features (hyperCalcemia, Renal failure, Anemia and Bone lesion), which profoundly affect both the Health-Related Quality of Life (HRQoL) and the life expectancy of patients. Despite all enhancement and improvement in therapeutic strategies, MM is almost incurable, and patients faced to this disease eventually relapse. Curcumin is an active and nontoxic phenolic compound, isolated from the rhizome of Curcuma longa L. It has been widely studied and has a confirmed broad range of therapeutic properties, especially anticancer activity, including anti-proliferation, anti-angiogenesis, antioxidant and anti-mutation activities. Curcumin induces apoptosis in cancerous cells and prevents Multidrug Resistance (MDR). Growing evidence concerning the therapeutic properties of curcumin caused a pharmacological impact on MM. It is confirmed that curcumin interferes with various signaling pathways and cell cycle checkpoints, and with oncogenes. In this paper, we summarized the anti-MM effects of curcumin.
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Dates et versions

hal-02955111 , version 1 (01-10-2020)

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Citer

Hamed Mirzaei, Hossein Bagheri, Faezeh Ghasemi, Jaber Khoi, Mohammad Pourhanifeh, et al.. Anti-Cancer Activity of Curcumin on Multiple Myeloma. Anti-Cancer Agents in Medicinal Chemistry, 2020, 20, ⟨10.2174/1871520620666200918113625⟩. ⟨hal-02955111⟩
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