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Article Dans Une Revue Stem Cell Research Année : 2020

Generation of the induced pluripotent stem cell line UHOMi002-A from peripheral blood mononuclear cells of a healthy male donor

Résumé

Evidence highlights the concept of multiple trajectories leading to COPD. Early-life events (i.e., in utero lung development) may influence the maximally attained lung function and increase the risk to develop COPD. Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development. We generated hiPSC lines from four highly characterized COPD patients with early onset and severe phenotype. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using integration-free Sendai Virus. The cell lines had normal karyotype, expressed pluripotency hallmarks, and differentiated into the three primary germ layers. These lines offer a tool to study early-life origins of COPD.
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hal-02965353 , version 1 (28-10-2020)

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Mathieu Fieldes, Engi Ahmed, Chloé Bourguignon, Joffrey Mianné, Martin Mélanie, et al.. Generation of the induced pluripotent stem cell line UHOMi002-A from peripheral blood mononuclear cells of a healthy male donor. Stem Cell Research, 2020, pp.102037. ⟨10.1016/j.scr.2020.102037⟩. ⟨hal-02965353⟩
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