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Article Dans Une Revue EMBO Journal Année : 2020

SARS-CoV-2 targets neurons of 3D human brain organoids

Résumé

COVID-19 pandemic caused by SARS-CoV-2 infection is a public health emergency. COVID-19 typically exhibits respiratory illness. Unexpectedly, emerging clinical reports indicate that neurological symptoms continue to rise, suggesting detrimental effects of SARS-CoV-2 on the central nervous system (CNS). Here, we show that a Düsseldorf isolate of SARS-CoV-2 enters 3D human brain organoids within 2 days of exposure. We identified that SARS-CoV-2 preferably targets neurons of brain organoids. Imaging neurons of organoids reveal that SARS-CoV-2 exposure is associated with altered distribution of Tau from axons to soma, hyperphosphorylation, and apparent neuronal death. Our studies, therefore, provide initial insights into the potential neurotoxic effect of SARS-CoV-2 and emphasize that brain organoids could model CNS pathologies of COVID-19.
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Dates et versions

hal-02969415 , version 1 (16-10-2020)

Identifiants

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Anand Ramani, Lisa Müller, Philipp N Ostermann, Elke Gabriel, Pranty Abida-Islam, et al.. SARS-CoV-2 targets neurons of 3D human brain organoids. EMBO Journal, 2020, 39 (20), pp.e106230. ⟨10.15252/embj.2020106230⟩. ⟨hal-02969415⟩
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