Biosynthesis of the pyoverdine siderophore of Pseudomonas aeruginosa involves precursors with a myristic or a myristoleic acid chain - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue FEBS Letters Année : 2011

Biosynthesis of the pyoverdine siderophore of Pseudomonas aeruginosa involves precursors with a myristic or a myristoleic acid chain

Melissa Hannauer
  • Fonction : Auteur
Mathias Schaefer
  • Fonction : Auteur
Francoise Hoegy
  • Fonction : Auteur
  • PersonId : 1078967
Patrick Wehrung
  • Fonction : Auteur
Gaetan Mislin
  • Fonction : Auteur
  • PersonId : 1077165
Herbert Budzikiewicz
  • Fonction : Auteur

Résumé

Pyoverdine I (PVDI) is the major siderophore produced by Pseudomonas aeruginosa to import iron. Biosynthesis of this chelator involves non‐ribosomal peptide synthetases and other enzymes. PvdQ is a periplasmic enzyme from the NTN hydrolase family and is involved in the final steps of PVDI biosynthesis. A pvdQ mutant produces two non‐fluorescent PVDI precursors with a higher molecular mass than PVDI. In the present study, we describe the use of mass spectrometry to determine the structure of these PVDI precursors and show that they both contain a unformed chromophore like ferribactin, and either a myristic or myristoleic chain that must be removed before PVDI is secreted into the extracellular medium.

Domaines

Autre [q-bio.OT]

Dates et versions

hal-02981372 , version 1 (27-10-2020)

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Citer

Melissa Hannauer, Mathias Schaefer, Francoise Hoegy, Patrick Gizzi, Patrick Wehrung, et al.. Biosynthesis of the pyoverdine siderophore of Pseudomonas aeruginosa involves precursors with a myristic or a myristoleic acid chain. FEBS Letters, 2011, 586 (1), pp.96-101. ⟨10.1016/j.febslet.2011.12.004⟩. ⟨hal-02981372⟩

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