Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Acta Biomaterialia Année : 2020

Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects

Résumé

Copper is an essential trace element required for human life, and is involved in several physiological mechanisms. Today researchers have found and confirmed that Cu has biological properties which are particularly useful for orthopedic biomaterials applications such as implant coatings or biodegradable filler bone substitutes. Indeed, Cu exhibits antibacterial functions, provides angiogenic ability and favors osteogenesis; these represent major key points for ideal biomaterial integration and the healing process that follows. The antibacterial performances of copper-doped biomaterials present an interesting alternative to the massive use of prophylactic antibiotics and help to limit the development of antibiotic resistance. By stimulating blood vessel growth and new bone formation, copper contributes to the improved bio-integration of biomaterials. This review describes the bio-functional advantages offered by Cu and focuses on the antibacterial, angiogenic and osteogenic properties of Cu-doped biomaterials with potential for orthopedic applications.

Domaines

Matériaux
Fichier principal
Vignette du fichier
Revue_cuivre_Acta Bio.pdf (681.79 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02984809 , version 1 (29-11-2020)

Identifiants

Citer

Aurélie Jacobs, Guillaume Renaudin, Christiane Forestier, J.-M. Nedelec, Stéphane Descamps. Biological properties of copper-doped biomaterials for orthopedic applications: A review of antibacterial, angiogenic and osteogenic aspects. Acta Biomaterialia, 2020, 117, pp.21-39. ⟨10.1016/j.actbio.2020.09.044⟩. ⟨hal-02984809⟩
84 Consultations
623 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More