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Article Dans Une Revue Organic Letters Année : 2020

Deprotonative Functionalization of the Difluoromethyl Group

Résumé

The functionalization of 3-(difluoromethyl)pyridine has been developed via direct deprotonation of-CHF2 with a lithiated base and subsequent trapping with various electrophiles in THF. In situ quench gives access to 3-pyridyl-CF2-SiMe2Ph as a new silylated compound, which can be post-functionalized with a fluoride source to obtain a larger library of 3-(difluoroalkyl)pyridines that were not accessible via direct deprotonation.

Domaines

Chimie organique
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Dates et versions

hal-02989088 , version 1 (05-11-2020)

Identifiants

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Laura Santos, Armen Panossian, Morgan Donnard, Jean-Pierre Vors, Sergii Pazenok, et al.. Deprotonative Functionalization of the Difluoromethyl Group. Organic Letters, 2020, ⟨10.1021/acs.orglett.0c03380⟩. ⟨hal-02989088⟩
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