Alpha technology: A powerful tool to detect mouse brain intracellular signaling events - CNRS - Centre national de la recherche scientifique Access content directly
Journal Articles Journal of Neuroscience Methods Year : 2020

Alpha technology: A powerful tool to detect mouse brain intracellular signaling events

Marion Zanese
  • Function : Author
Giovanni Tomaselli
  • Function : Author
Valérie Roullot-Lacarrière
  • Function : Author
Maïté Moreau
  • Function : Author
Luigi Bellocchio
  • Function : Author
Agnès Grel
  • Function : Author
Giovanni Marsicano
Nathalie Sans
Monique Vallée

Abstract

Phosphorylation by protein kinases is a fundamental molecular process involved in the regulation of signaling activities in living organisms. Understanding this complex network of phosphorylation, especially phosphoproteins, is a necessary step for grasping the basis of cellular pathophysiology. Studying brain intracellular signaling is a particularly complex task due to the heterogeneous complex nature of the brain tissue, which consists of many embedded structures.
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Marion Zanese, Giovanni Tomaselli, Valérie Roullot-Lacarrière, Maïté Moreau, Luigi Bellocchio, et al.. Alpha technology: A powerful tool to detect mouse brain intracellular signaling events. Journal of Neuroscience Methods, 2020, 332, pp.108543. ⟨10.1016/j.jneumeth.2019.108543⟩. ⟨hal-02990027⟩

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