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Article Dans Une Revue New Journal of Chemistry Année : 2020

New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials

Nawal Fodil Cherif
  • Fonction : Auteur
Oualid Hamdaoui
  • Fonction : Auteur
Fabrice Leroux
Christine Taviot-Guého
  • Fonction : Auteur

Résumé

This paper describes the intercalation of ciprofloxacin (CIP), a bactericidal antibiotic, into the interlayer space of layered double hydroxides (LDHs). To counter the problem of bacterial resistance and also to improve the properties of the CIP drug, the drug carrier approach promises significant benefits. Through the tight control over the synthesis parameters, particularly the amounts of CIP with respect to aluminum ions, two different LDH-CIP-intercalated structures were obtained with significantly different interlayer distances, namely, 21 and 32 Å. The samples were fully characterized in terms of composition, structure, and morphology. Interestingly, the structure with the largest interlayer distance incorporated both CIP anions and Al(CIP)3 complex, exhibiting the possibility to increase the CIP drug loading beyond the anionic-exchange capacity of the LDH carrier. In vitro release in a simulated intestinal fluid (phosphate-buffered solution at pH 7.5) confirmed that LDH was a potentially efficient carrier to deliver CIP in a sustained manner via the anion- exchange mechanism. Different release rates were observed depending on the intercalated structure, which were also influenced by the morphological characteristics.

Domaines

Chimie Matériaux
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Dates et versions

hal-02992475 , version 1 (23-11-2020)

Identifiants

Citer

Nawal Fodil Cherif, Vera Regina Leopoldo Constantino, Oualid Hamdaoui, Fabrice Leroux, Christine Taviot-Guého. New insights into two ciprofloxacin-intercalated arrangements for layered double hydroxide carrier materials. New Journal of Chemistry, 2020, 44 (24), pp.10076-10086. ⟨10.1039/D0NJ00045K⟩. ⟨hal-02992475⟩
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