Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Current Biology - CB Année : 2021

Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism

Vincent Bayle
Yvon Jaillais

Résumé

Graphical Abstract Highlights d MAKR2 is co-expressed with PIN2 and regulates the pace of root gravitropism d MAKR2 controls PIN2 asymmetric accumulation at the root level during gravitropism d MAKR2 binds to and is a negative regulator of the TMK1 receptor kinase d Auxin antagonizes the MAKR2 inhibition of TMK1 by delocalizing MAKR2 in the cytosol In Brief Marquè s-Bueno, Armengot et al. show that the unstructured protein MAKR2 controls the dynamics of the root gravitropic response by acting as a negative regulator of the TMK1 receptor kinase. In addition, the MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2 membrane dissociation in a TMK1-dependent manner.
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Dates et versions

hal-03000945 , version 1 (12-11-2020)

Identifiants

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Maria Mar Marquès-Bueno, Laia Armengot, Lise C Noack, Joseph Bareille, Lesia Rodriguez, et al.. Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism. Current Biology - CB, 2021, 31, pp.1 - 10. ⟨10.1016/j.cub.2020.10.011⟩. ⟨hal-03000945⟩
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