Enantioselective Gold-Catalyzed Pictet–Spengler Reaction
Résumé
Cationic chiral Au(I) complexes catalyze asymmetric Pictet−Spengler reactions between tryptamines and arylaldehydes. The resulting tetrahydro-β-carbolines are obtained with wide functional group tolerance in high yield and with high enantioselectivities (up to 95%). Aldehydes bearing polar or protic functions are well tolerated. The reaction features a hitherto unknown C2-auration of the indole as the key step, supported by density functional theory calculations.
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