@article{swaren:hal-03004753, TITLE = {{Electrostatic analysis of TEM1 -lactamase: effect of substrate binding, steep potential gradients and consequences of site-directed mutations}}, AUTHOR = {Swar{\'e}n, Peter and Maveyraud, Laurent and Guillet, Val{\'e}rie and Masson, Jean-Michel and Mourey, Lionel and Samama, Jean Pierre}, URL = {https://hal-cnrs.archives-ouvertes.fr/hal-03004753}, JOURNAL = {{Structure}}, PUBLISHER = {{Elsevier (Cell Press)}}, VOLUME = {3}, NUMBER = {6}, PAGES = {603-613}, YEAR = {1995}, MONTH = Jun, DOI = {10.1016/s0969-2126(01)00194-0}, KEYWORDS = {antibiotics ; 3-lactamas'e ; electrostatics ; hydrolysis ; substrate-triggered mechanism}, PDF = {https://hal-cnrs.archives-ouvertes.fr/hal-03004753/file/swaren-structure95.pdf}, HAL_ID = {hal-03004753}, HAL_VERSION = {v1}, }