%0 Journal Article %T Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum %+ Columbia University Irving Medical Center (CUIMC) %+ University of the Study of Campania Luigi Vanvitelli %+ Columbia University [New York] %+ Centre International de Recherche en Infectiologie (CIRI) %A Weisberg, Stuart %A Connors, Thomas %A Zhu, Yun %A Baldwin, Matthew %A Lin, Wen-Hsuan %A Wontakal, Sandeep %A Szabo, Peter %A Wells, Steven %A Dogra, Pranay %A Gray, Joshua %A Idzikowski, Emma %A Stelitano, Debora %A Bovier, Francesca %A Davis-Porada, Julia %A Matsumoto, Rei %A Poon, Maya Meimei Li %A Chait, Michael %A Mathieu, Cyrille %A Horvat, Branka %A Decimo, Didier %A Hudson, Krystalyn %A Zotti, Flavia Dei %A Bitan, Zachary %A La Carpia, Francesca %A Ferrara, Stephen %A Mace, Emily %A Milner, Joshua %A Moscona, Anne %A Hod, Eldad %A Porotto, Matteo %A Farber, Donna %< avec comité de lecture %@ 1529-2908 %J Nature Immunology %I Nature Publishing Group %P 25-31 %8 2020-11-05 %D 2020 %R 10.1038/s41590-020-00826-9 %Z Life Sciences [q-bio]Journal articles %X Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C)3-5. Here, we show distinct antibody responses in children and adults after SARS-CoV-2 infection. Adult COVID-19 cohorts had anti-spike (S) IgG, IgM and IgA antibodies, as well as anti-nucleocapsid (N) IgG antibody, while children with and without MIS-C had reduced breadth of anti-SARS-CoV-2-specific antibodies, predominantly generating IgG antibodies specific for the S protein but not the N protein. Moreover, children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children independent of whether they develop MIS-C, with implications for developing age-targeted strategies for testing and protecting the population. %G English %2 https://cnrs.hal.science/hal-03008774/document %2 https://cnrs.hal.science/hal-03008774/file/36787_2_merged_1603385760.pdf %L hal-03008774 %U https://cnrs.hal.science/hal-03008774 %~ INSERM %~ ENS-LYON %~ CNRS %~ UNIV-LYON1 %~ CIRI %~ UDL %~ UNIV-LYON