A Self-Assembling NHC-Pd-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction in Water - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Molecules Année : 2020

A Self-Assembling NHC-Pd-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction in Water

Résumé

Nanoformulated calix[8]arenes functionalized with N-heterocyclic carbene (NHC)-palladium complexes were found to be efficient nano-reactors for Suzuki-Miyaura cross-coupling reactions of water soluble iodo-and bromoaryl compounds with cyclic triol arylborates at low temperature in water without any organic co-solvent. Combined with an improved one-step synthesis of triol arylborates from boronic acid, this remarkably efficient new tool provided a variety of 4-arylated phenylalanines and tyrosines in good yields at low catalyst loading with a wide functional group tolerance.

Domaines

Chimie organique
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Dates et versions

hal-03009690 , version 1 (17-11-2020)

Identifiants

Citer

Arnaud Peramo, Ibrahim Abdellah, Shannon Pecnard, Julie Mougin, Cyril Martini, et al.. A Self-Assembling NHC-Pd-Loaded Calixarene as a Potent Catalyst for the Suzuki-Miyaura Cross-Coupling Reaction in Water. Molecules, 2020, 25 (6), pp.1459. ⟨10.3390/molecules25061459⟩. ⟨hal-03009690⟩
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