Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
Résumé
Highlights d Fragile X cells have increased DNA damage with or without DNA replication stress d Break-seq identifies genome-wide DNA double-strand breaks in fragile X cells d Fragile X cells have elevated R-loop formation under DNA replication stress d FMRP, but not a disease-causing FMRP-I304N mutant, reduces R-loop-induced DSBs
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