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Article Dans Une Revue Journal for Immunotherapy of Cancer Année : 2020

Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies.

Laurence Moine

Résumé

Intratumorous immunotherapy for cancer is currently thriving. The aim of such local strategy is to improve the therapeutic index of these treatments, for higher on-target/on-tumor activity and less on-target/off-tumor adverse events. Strategies allowing for slow release of anti-CTLA4 in the tumor microenvironment could improve their clinical efficacy.The purpose of the study was to develop a radiopaque delivery platform to improve the targeting and exposure of intratumorous anti-CTLA4 antibodies for cancer immunotherapy.

Domaines

Immunothérapie
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Dates et versions

hal-03019803 , version 1 (23-11-2020)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Lambros Tselikas, Thierry de Baere, Thomas Isoardo, Sandrine Susini, Karine Ser-Le Roux, et al.. Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies.. Journal for Immunotherapy of Cancer, 2020, 8 (1), ⟨10.1136/jitc-2020-000579⟩. ⟨hal-03019803⟩
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