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Article Dans Une Revue Frontiers in Chemistry Année : 2020

Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil

Yan Zhang
Eddy Petit
S.M. Li

Résumé

Dynamic hydrogels have been prepared by cross-linking of O-carboxymethyl chitosan (O-CMCS) with reversibly connected imino-PEGylated dynamers. The double imine chitosan/dynamer and dynamer bonds and were used to provide tighter structures and adaptive drug release behaviors of the hydrogels. The structural and physical properties of the resulted hydrogels were examined, showing good thermal stability and higher swelling behaviors (up to 3,000%). When hydrogels with various composition ratios were further applied for delivery of anti-cancer drug fluorouracil (5-FU), high drug encapsulation rates were recorded, up to 97%. The release profile of 5-FU showed fast rate at the beginning, followed by slow increase to the maximum amount within 12 h, demonstrating potential as drug carriers for efficient drug delivery.
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Dates et versions

hal-03028915 , version 1 (27-11-2020)

Identifiants

Citer

Yan Zhang, Chi-Yen Pham, Rui Yu, Eddy Petit, S.M. Li, et al.. Dynamic Hydrogels Based on Double Imine Connections and Application for Delivery of Fluorouracil. Frontiers in Chemistry, 2020, 8, pp.739. ⟨10.3389/fchem.2020.00739⟩. ⟨hal-03028915⟩
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