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Article Dans Une Revue Development (Cambridge, England) Année : 2015

BMP signalling controls the construction of vertebrate mucociliary epithelia

Marie Cibois
  • Fonction : Auteur
Guillaume Luxardi
  • Fonction : Auteur
B Chevalier
  • Fonction : Auteur
V Thome
  • Fonction : Auteur
Olivier Mercey
  • Fonction : Auteur
L-E Zaragosi
  • Fonction : Auteur
Pascal Barbry
Andrea Pasini
  • Fonction : Auteur
Laurent Kodjabachian
  • Fonction : Auteur
  • PersonId : 1084770

Résumé

Despite the importance of mucociliary epithelia in animal physiology, the mechanisms controlling their establishment are poorly understood. Using the developing Xenopus epidermis and regenerating human upper airways, we reveal the importance of BMP signalling for the construction of vertebrate mucociliary epithelia. In Xenopus, attenuation of BMP activity is necessary for the specification of multiciliated cells (MCCs), ionocytes and small secretory cells (SSCs). Conversely, BMP activity is required for the proper differentiation of goblet cells. Our data suggest that the BMP and Notch pathways interact to control fate choices in the developing epidermis. Unexpectedly, BMP activity is also necessary for the insertion of MCCs, ionocytes and SSCs into the surface epithelium. In human, BMP inhibition also strongly stimulates the formation of MCCs in normal and pathological (cystic fibrosis) airway samples, whereas BMP overactivation has the opposite effect. This work identifies the BMP pathway as a key regulator of vertebrate mucociliary epithelium differentiation and morphogenesis.
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Dates et versions

hal-03044385 , version 1 (07-12-2020)

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Marie Cibois, Guillaume Luxardi, B Chevalier, V Thome, Olivier Mercey, et al.. BMP signalling controls the construction of vertebrate mucociliary epithelia. Development (Cambridge, England), 2015, 142, pp.2352 - 2363. ⟨10.1242/dev.118679⟩. ⟨hal-03044385⟩
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