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Article Dans Une Revue Journal of Physiology and Biochemistry Année : 2020

The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues

Audrey Carrière
Damien Lagarde
Yannick Jeanson
Jean-Charles Portais
Isabelle Ader
Louis Casteilla

Résumé

Thermogenic (brown and beige) adipose tissues improve glucose and lipid homeostasis and therefore represent putative targets to cure obesity and related metabolic diseases including type II diabetes. Beside decades of research and the very well-described role of noradrenergic signaling, mechanisms underlying adipocytes plasticity and activation of thermogenic adipose tissues remain incompletely understood. Recent studies show that metabolites such as lactate control the oxidative capacity of thermogenic adipose tissues. Long time viewed as a metabolic waste product, lactate is now considered as an important metabolic substrate largely feeding the oxidative metabolism of many tissues, acting as a signaling molecule and as an inter-cellular and inter-tissular redox carrier. In this review, we provide an overview of the recent findings highlighting the importance of lactate in adipose tissues, from its production to its role as a browning inducer and its metabolic links with brown adipose tissue. We also discuss additional function(s) than thermogenesis ensured by brown and beige adipose tissues, i.e., their ability to dissipate high redox pressure and oxidative stress thanks to the activity of the uncoupling protein-1, helping to maintain tissue and whole organism redox homeostasis and integrity.
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Dates et versions

hal-03059917 , version 1 (05-02-2021)

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Citer

Audrey Carrière, Damien Lagarde, Yannick Jeanson, Jean-Charles Portais, Anne Galinier, et al.. The emerging roles of lactate as a redox substrate and signaling molecule in adipose tissues. Journal of Physiology and Biochemistry, 2020, 76 (2), pp.241-250. ⟨10.1007/s13105-019-00723-2⟩. ⟨hal-03059917⟩
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