Topoisomerase I prevents transcription-replication conflicts at transcription termination sites - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Molecular & Cellular Oncology Année : 2021

Topoisomerase I prevents transcription-replication conflicts at transcription termination sites

Résumé

R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops, we mapped RNA:DNA hybrids, markers of replication fork stalling and DNA double-strand breaks along the human genome. This analysis indicates that transient replication fork pausing occurs at the transcription termination sites of highly expressed genes enriched in R-loops and prevents head-on conflicts with transcription, in a topoisomerase I-dependent manner.
Fichier principal
Vignette du fichier
Topoisomerase I prevents transcription replication conflicts at transcription termination sites.pdf (2.74 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03083175 , version 1 (18-12-2020)

Identifiants

Citer

Yaqun Liu, Yea-Lih Lin, Philippe Pasero, Chun-Long Chen. Topoisomerase I prevents transcription-replication conflicts at transcription termination sites. Molecular & Cellular Oncology, 2021, 8 (1), pp.e1843951-3. ⟨10.1080/23723556.2020.1843951⟩. ⟨hal-03083175⟩
37 Consultations
63 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More