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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2020

SFPH proteins as therapeutic targets for a myriad of diseases

Résumé

The stomatin/prohibitin/flotillin/HflK/HflC (SPFH) domain is present in an evolutionarily conserved family of proteins that regulate a myriad of signaling pathways in archaea, bacteria and eukaryotes. The most studied SPFH proteins, prohibitins, have already been targeted by different families of small molecules to induce anticancer, cardioprotective, anti-inflammatory, antiviral, and antiosteoporotic activities. Ligands of other SPFH proteins have also been identified and shown to act as anesthetics, anti-allodynia, anticancer, and anti-inflammatory agents. These findings indicate that modulators of human or bacterial SPFH proteins can be developed to treat a wide variety of human disorders.
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Dates et versions

hal-03092105 , version 1 (11-01-2021)

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Dong Wang, Redouane Tabti, Sabria Elderwish, Amel Djehal, Nora Chouha, et al.. SFPH proteins as therapeutic targets for a myriad of diseases. Bioorganic and Medicinal Chemistry Letters, 2020, 30 (22), pp.127600. ⟨10.1016/j.bmcl.2020.127600⟩. ⟨hal-03092105⟩
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