DLX5 (distal-less homeobox 5) - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Atlas of Genetics and Cytogenetics in Oncology and Haematology Année : 2014

DLX5 (distal-less homeobox 5)

Yorick Gitton
Giovanni Levi

Résumé

DLX5 belongs to the six-member family of DLX genes characterized by a homeobox related to that found in the insect Distal-less (Dll) gene. The sixDLX genes are organized as three bigenic pairs with a tail-to-tail orientation (Zerucha et al., 2000) and located on chromosomes where HOX clusters are also found (DLX5/DLX6; 7q21.3, syntenic to the HOXA cluster), (DLX1/DLX2; 2q32, syntenic to the HOXD cluster; Simeone et al., 1994) and (DLX3/DLX4; 17q21.33, syntenic to the HOXB cluster). During embryonic development DLX genes are involved in the control of appendage and craniofacial morphogenesis and in the differentiation of reproductive organs; in the adult they play a role in bone homeostasis and in the maintenance of tissue integrity.
Fichier principal
Vignette du fichier
03-2014-DLX5ID44295ch7q21.pdf (744.26 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03092626 , version 1 (02-01-2021)

Identifiants

Citer

Yorick Gitton, Giovanni Levi. DLX5 (distal-less homeobox 5). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014, 18 (11), pp.810-816. ⟨10.4267/2042/54163⟩. ⟨hal-03092626⟩

Collections

INSERM MNHN CNRS
21 Consultations
35 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More