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Article Dans Une Revue Scientific Reports Année : 2021

Identification of a new regulation pathway of EGFR and E-cadherin dynamics

Résumé

E-cadherin and EGFR are known to be closely associated hence regulating differentiation and proliferation notably in epithelia. We have previously shown that galectin-7 binds to E-cadherin and favors its retention at the plasma membrane. In this study, we shed in light that galectin-7 establishes a physical link between E-cadherin and EGFR. Indeed, our results demonstrate that galectin-7 also binds to EGFR, but unlike the binding to E-cadherin this binding is sugar dependent. The establishment of E-cadherin/EGFR complex and the binding of galectin-7 to EGFR thus lead to a regulation of its signaling and intracellular trafficking allowing cell proliferation and migration control. In vivo observations further support these results since an epidermal thickening is observed in galectin-7 deficient mice. This study therefore reveals that galectin-7 controls epidermal homeostasis through the regulation of E-cadherin/EGFR balance.
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Dates et versions

hal-03098373 , version 1 (28-11-2022)

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Paternité

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Véronique Proux-Gillardeaux, Tamara Advedissian, Charlotte Perin, Jean-Christophe Gelly, Mireille Viguier, et al.. Identification of a new regulation pathway of EGFR and E-cadherin dynamics. Scientific Reports, 2021, 11, pp.22705. ⟨10.1038/s41598-021-02042-3⟩. ⟨hal-03098373⟩
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