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Article Dans Une Revue Advanced Drug Delivery Reviews Année : 2020

Exosomes and GPI-anchored proteins: judicious pairs for investigating biomarkers from body fluids

Résumé

Exosomes are 50-100 nm membranous vesicles actively released by cells which can be indicative of a diseased cell status. They contain various kinds of molecule-proteins, mRNA, miRNA, lipids ¬-that are actively being studied as potential biomarkers. Hereafter I put forward several arguments in favor of the potential use of glycosylphosphatidylinositol-anchored proteins (GPI-APs) as biomarkers especially of cancerous diseases. I will briefly update readers on the exosome field and review various features of GPI-APs, before further discussing the advantages of this class of proteins as potential exosomal biomarkers. I will finish with a few examples of exosomal GPI-APs that have already been demonstrated to be good prognostic markers, as well as innovative approaches developed to quantify these exosomal biomarkers.
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Dates et versions

hal-03100113 , version 1 (06-01-2021)

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Michel Vidal. Exosomes and GPI-anchored proteins: judicious pairs for investigating biomarkers from body fluids. Advanced Drug Delivery Reviews, 2020, ⟨10.1016/j.addr.2020.08.006⟩. ⟨hal-03100113⟩
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